CORE FACILITYThe Laboratory has flexible capacities to take in projects from research groups within the University of Debrecen. We are offering RESEARCH & DEVELOPMENT COLLABORATIONS - subject to joint grant application or with a minimum contribution of 50% of all costs incurred by the project in question. JOINT GRANT APPLICATIONS - we encourage researchers to incorporate costs of core services into grant applications, based on our cost estimate, or to nominate us in the applications as partners. CONSULTATION - we are happy to help you in designing joint projects, or give scientific advise in your projet design to a limited extent, depending on available capacities. SERVICES - we provide services based on rigorous project design and cost calculation - see SERVICES menu item for more information on possibilities. PRODUCTS - we have ready-made products (cytokines, recombinant proteins) - see PRODUCTS menu items for more information - and have a strong pipeline and workflow for new product developments to meet your needs (e.g. custom cytokine production development - you name a cytokine, we produce it for you with QC within a couple of months).
Please, have a look at our INFRASTRUCTURE and TECHNOLOGIES for infromation on our capacities, competencies and possibilities.
COLLABORATIVE AND SERVICE PROJECT EXAMPLES (SINCE 2010) - UNIVERSITY OF DEBRECEN and its SPIN-OFF COMPANIES - Purification and characterisation (Western) of a rabbit polyclonal anti-SMRT antibody - Cloning and expression of an Fc-fusion protein. - Production and purification of PNGase F enzyme in E. coli for glycoanalytic applications. - Production and purification of human TG2 in HEK293T cell line using transient transfection. - Production of recombinant human IL.-4, GM-CSF, LIF etc. for monocyte differentiation into dendritic cell and ES cell culture sustainance. - Purification of -anti-TG2 minibodies produced in HEK293T cells. - Purification of mouse monoclonal antibodies from hybridoma culture supernatants. - ChIP-grade mouse monoclonal anti-RARa antibody development, purification and characterisation (Western, ChIP-qPCR, ChIP-Seq) - Peptide phage display library-base epitope mapping of tear protein depletion antibodies. - Soluble receptor detection (Western) and quantification ( ELISA,) in culture supernatants and patient samples.
For references, see the COLLABORATIONS section.
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Links & Partners
Magyar Gazdaságfejlesztési Központ
Center for Clinical Genomics and Personalised medicine
Nuclear Hormon Receptor Research Laboratory - NLAB
Department of Biochemistry and Molecular Biology
Medical and Health Science Center
Research Center for Molecular Medicine
UD-GenoMed Medical Genomic Technologies Ltd
Customers' Wishlist
I need
... a custom stable cell line!
... purified recombinant proteins!
... a custom monoclonal antibody!
... cytokines for my research!
... engineered proteins!
... a protein with novel functions!
Contact PROXENCELL
Dr. Zsolt Keresztessy, PhD MBA
Protein Expression and Cell Engineering Laboratory
Center for Clinical Genomics and Personalised Medicine
Nagyerdei krt 98, Debrecen H-4032 Hungary
Tel: +36 52 411 717 / 50226, 50206
e-mail: zsolt.keresztessy@med.unideb.hu
Find us:
Room 3.2.5 and Lab3.26, IVDI Building, Medical and Health Sciences Center
ORDERING INFO: LINK
News
Protein Expression Services
Protein expression services are opening for the University of Debrecen from May 2012.
Recombinant Human IL-4
Recombinant human IL-4 is available for purchase either in the form of IL-4 containing culture medium (use 1:10 dilution) or in purified form. The protein is produced in HEK293T cells, batch-tested by Western blotting, ELISA, TF-1 proliferation assay, and against endotoxins. See product sheet. Please, order online.
Polyclonal anti-SMRT antibody
Rabbit polyclonal anti-SMRT antibody is available for purchase. The antibody is protein-A purified, Western, IP, IHC, ChIP tested. See product sheet.
Gene-to-Protein Services
We deliver full service from custom DNA sequence to purified recombinant protein. Individually available service components are cloning, expression, purification, and characterisation of your protein of interest.
Stable Cell Line Development
We offer state-of-the-art Cell and Genome Engineering technologies to generate custom stable cell lines for research, bioassays and protein production. Site-specific gene mutations, deletions, insertions, gene insertions, multiple transgenic cell lines.
Monoclonal antibody development
You provide a custom target sequence – we produce specific mouse monoclonal antibodies.
Epitope design, peptide synthesis, immunisation, hybridoma generation and screening, antibody production, purification and characterisation.
Cytokine Development Services
If you need a cytokine at an affordable price for your research - we produce it for you. The workflow includes gene design and optimisation, gene synthesis, cloning into expression vectors, expression, purification and biochemical/biological characterisation of your recombinant cytokines.
Recombinant proteins
We offer special services and consultation in the field of custom recombinant protein development, engineering, design, and evolution, including mutagenesis, library generation, directed molecular evolution, phage display technology, HTS screening.
Antibodies and cytokines at great prices
Cytokine products:
human IL-4, IL-2, GM-CSF,
mouse IL-4
Coming soon: LIF, IL-9, IL-15